Sing an optical fiber thermometer. The frequency and amplitude with the field have been 600 kHz and 2.9 kA/m, respectively. As a control experiment to investigate the milling effect around the magnetic hyperthermiarelated properties, the temperature profile of a mixture of Fe3O4 (ten mass ) and HA was also measured, which was obtained by vigorously stirring the suspensions of Fe3O4 and HA just after they had been individually prepared based on the abovementioned strategies. four. Conclusions A very simple mechanochemical strategy for the fast synthesis of Fe3O4/HA composites was developed. In this technique, superparamagnetic Fe3O4 nanoparticles and submicronsized HA particles are sequentially ready inside a short period at area temperature, and Fe3O4 nanoparticles are correctly incorporated into the HA matrix by milling. Within this study, the milling time necessary to acquire Fe3O4/HA composites was only 1 h. Inside the Fe3O4/HA composites thus synthesized, the Fe3O4 nanoparticles had been observed to become homogeneously dispersed with out obtaining formed any big aggregates, even within the absence of antiagglomeration agents, illustrating the success of your milling approach. This home resulted in powerful heat generation in the Fe3O4/HA composites when the composites have been immersed in an alternating magnetic field. The HA powder synthesized by our system was determined to become lowcrystalline Btype carbonate HA, which is appropriate to serve as a bonesubstitute material. As a result, our synthesis system can effectively deliver Fe3O4/HA composites that may perhaps be utilized in hyperthermia therapy against malignant bone tumors. Future work will concentrate around the improvement on the hyperthermiarelated properties of the material by Fe3O4 nanoparticle size optimization and also on applications in the components in bone tissue engineering. Conflict of Interest The authors declare no conflict of interest. References 1. two. Ding, C.C.; Teng, S.H.; Pan, H. In situ generation of chitosan/hydroxyapatite composite microspheres for biomedical application. Mater. Lett. 2012, 79, 724. Nikpour, M.R.; Rabiee, S.M.; Jahanshahi, M. Synthesis and characterization of hydroxyapatite/chitosan nanocomposite components for healthcare engineering applications.Formula of 2091009-80-0 Compos.1846598-27-3 web B Eng.PMID:25558565 2012, 43, 1881886. Zhang, J.; Liu, G.; Wu, Q.; Zuo, J.; Qin, Y.; Wang, J. Novel mesoporous hydroxyapatite/chitosan composite for bone repair. J. Bionic. Eng. 2012, 9, 24351.three.Int. J. Mol. Sci. 2013, 14 four.five.six. 7. 8.9. 10.11.12.13.14.15.16. 17. 18. 19.Tien, W.B.; Chen, M.T.; Yao, P.C. Effects of pH and temperature on microstructure and morphology of hydroxyapatite/collagen composites synthesized in vitro. Mater. Sci. Eng. C 2012, 32, 2096102. Wei, Q.; Lu, J.; Ai, H.; Jiang, B. Novel technique for the fabrication of multiscale structure collagen/hydroxyapatitemicrosphere composites based on CaCO3 microparticle templates. Mater. Lett. 2012, 80, 914. Kochi, A.; Kikuchi, M.; Shirosaki, Y.; Hayakawa, S.; Osaka, A. Preparation of injectable hydroxyapatite/collagen nanocomposite artificial bone. Crucial Eng. Mater. 2012, 49394, 68992. Chen, J.P.; Chang, F.N. Preparation and characterization of hydroxyapatite/gelatin composite membranes for immunoisolation. Appl. Surf. Sci. 2012, 262, 17683. Kailasanathan, C.; Selvakumar, N.; Naidu, V. Structure and properties of titania reinforced nanohydroxyapatite/gelatin biocomposites for bone graft materials. Ceram. Int. 2012, 38, 57179. Lahiri, D.; Ghosh, S.; Agarwal, A. Carbon nanotube reinforced hydroxyapatite composite for orthopedic appl.
