Postoperative wounds, donor and graft web pages and traumatic wounds. Diabetic and infected wounds. To avoid postoperative adhesions in thyroid and spine surgeries. Great for higher exuding wounds e.g., ulcers including diabetic and leg pressure ulcers. It eliminates odour and ideal for necrotic wounds and wounds with odours. Complete and partialthickness wounds, for ulcers like stress ulcers, venous ulcers, diabetic ulcers and seconddegree burns. Made use of for ulcers, diabetic wounds, pressure sores, ischemic, necrotic wounds. Utilized to cease bleeding in postoperative wounds, traumatic wounds, gun shots, skin graft donor sites, bleeding from accidents.
Int. J. Mol. Sci. 2013, 14, 1575515766; doi:10.3390/ijmsOPEN ACCESSInternational Journal ofMolecular SciencesISSN 14220067 www.mdpi.com/journal/ijms ArticleGalactosylated Chitosan Oligosaccharide Nanoparticles for Hepatocellular Carcinoma CellTargeted Delivery of Adenosine TriphosphateXiu Liang Zhu 1,, Yong Zhong Du 2,, Ri Sheng Yu 1,, Ping Liu 2, Dan Shi 1, Ying Chen 1, Ying Wang 1 and Fang Fang HuangDepartment of Radiology, the Second Affiliated Hospital, Zhejiang University College of Medicine, 88 Jiefang Road, Hangzhou 310009, China; EMails: [email protected] (X.L.Z.); [email protected] (D.S.); [email protected] (Y.C.); [email protected] (Y.W.); [email protected] (F.F.H.) Division of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China; EMails: [email protected] (Y.Z.D.); [email protected] (P.L.) These authors contributed equally to this work. Author to whom correspondence really should be addressed; Email: [email protected]; Tel./Fax: 8657188208439. Received: 27 April 2013; in revised kind: 7 July 2013 / Accepted: 23 July 2013 / Published: 29 JulyAbstract: Nanoparticles composed of galactosylated chitosan oligosaccharide (GalCSO) and adenosine triphosphate (ATP) had been prepared for hepatocellular carcinoma cellspecific uptake, along with the traits of GalCSO/ATP nanoparticles have been evaluated.Mn(TMHD)3 site CSO/ATP nanoparticles were ready as a control. The average diameter and zeta potential of GalCSO/ATP nanoparticles had been 51.03 three.26 nm and 30.50 1.25 mV, respectively, suggesting appropriate properties for a drug delivery method. Subsequently, the cytotoxicity of GalCSO/ATP nanoparticles were examined by the methyl tetrazolium (MTT) assay, and the half maximal inhibitory concentration (IC50) values had been calculated with HepG2 (human hepatocellular carcinoma cell line) cells.Formula of Methyl 4-hydroxythiophene-3-carboxylate The outcomes showed that the cytotoxic impact of nanoparticles on HepG2 cells was low.PMID:23381626 Inside the meantime, it was also located that the GalCSO/ATP nanoparticles could be uptaken by HepG2 cells, on account of expression of the asialoglycoprotein receptor (ASGPR) on their surfaces. The presented benefits indicate that the GalCSO nanoparticles may be pretty desirable to become used as an intracellular drugInt. J. Mol. Sci. 2013,delivery carrier for hepatocellular carcinoma cell targeting, as a result warranting additional in vivo or clinical investigations. Search phrases: galactosylated chitosan oligosaccharide; adenosine triphosphate; nanoparticles; hepatocyte uptake; targeted drug delivery1. Introduction Resulting from the current advances in material science and nanotechnology inside the previous handful of years, nanoparticles have turn out to be incredibly eye-catching for their applications within the fields of biology, medicine and bioimaging [1]. Nanoparticles is often utilized to reliably and safely provide proteins, drugs, vaccines and also other bio.
